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Diphenhydramine is an antihistamine used in the treatment of allergies, insect bites or stings and other causes of itching. It is also used for its sedative and antiemetic effects in the treatment of motion sickness and travel anxiety. It is also used for its antitussive effect. Availability: Diphenhydramine is a non-prescription (OTC) product available as 25mg and 50mg tablets or capsules as well. How this medicine should be used: Diphenhydramine is FDA approved for external use in dogs and cats. Diphenhydramine oral and injectable is not FDA approved for use in veterinary medicine; however, it is a commonly accepted practice to use this medication in dogs and cats. The usual dose in dogs and cats is 0.5-2mg/pound every 8-12 hours. The slow release capsule should not be mixed or dissolved in food. Do not use diphenhydramine found in combination products containing sinus or cold medicine. What are the side effects: Side effects of diphenhydramine include drowsiness, dry mouth and urinary Less